Probiotic for Honeybee

     Probiotics based on WHO/FAO definition are "live microorganisms that when consume in adequate amount, confer health benefit on host."

     There are several stresses in honeybee industry like climate changes, migration, feedstuff changes etc. that can weaken the immune system and cause gut microbial imbalance in honeybee. This factors can lead to several diseases, decrease in production and mortality. 

     Using probiotic supplements in honeybee hives can balance and optimize the gut microflora as well as promote the growth, improve the digestion and absorption, enhance the immune system performance and enhance the resistance to stresses and diseases. 

     Probio-Apis® is combination of nine bacteria and yeast probiotic strains that is specially formulated for honeybee hives based on in vitro and in vivo experiments. 

Mode of action of probiotics:

  • Preventing stress 
  • GI microflora balance 
  • Enhancing digestion and absorption 
  • Increasing resistance to diseases 
  • Preventing the growth of pathogenic agents 
  • Increasing and rebuilding intestinal microvilli 
  • Vitamin and enzyme production 

Benefits of Probio-Apis® in honeybee:

  • Improving weak hives 
  • Enhancing the immune system performance 
  • Resistance to diseases 
  • Re-establishment of gut microflora after antibiotic therapy 
  • Improving digestion and absorption 
  • Health improvement and mortality reduction in the hives 
  • Possibility of simultaneous use within supplements, anti-parasitic and other honeybee drugs 
  • Improving reproduction rate, increasing hive population 

Using Probio-Apis® is recommended in following conditions: 

  • Spring and autumn seasons 
  • Migration 
  • After antibiotic therapy 
  • At disease time
  • Decline in food sources     

Ingredients of Probio-Apis®:

  • Bacillus subtilis 
  • Saccharomyces cerevisiae 
  • Enterococcus faecium 
  • Pediococcus acidilactici 
  • Lactobacillus acidophilus 
  • Lactobacillus rhamnosus 
  • Lactobacillus plantarum 
  • Lactobacillus casei 
  • Bifidobacterium bifidum 
  • Total count: 107 cfu/g   


  • 10 g/hive daily 

Directions for use: 

Probio-Apis® can be used in following ways: 

  • Dissolved in cool sugar syrup 
  • Mixed with sugar and scattered on the combs 
  • Mixed with honeybee cake   


  • 100g cans, 500g pockets




Probiotic for Honeybee


Zist Darman Mahan Co.

Manufacturer of probiotic supplements for livestock, poultry and aquaculture


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